Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5’ extended long undecoded NDC80 transcript isoform. Here we demonstrate a transcriptional inter...

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Detalles Bibliográficos
Autores principales: Chia, Minghao, Tresenrider, Amy, Chen, Jingxun, Spedale, Gianpiero, Jorgensen, Victoria, Ünal, Elçin, van Werven, Folkert Jacobus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655139/
https://www.ncbi.nlm.nih.gov/pubmed/28906248
http://dx.doi.org/10.7554/eLife.27420

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