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Telomere DNA damage signaling regulates cancer stem cell evolution, epithelial mesenchymal transition, and metastasis

Chromosome ends are protected by telomeres that prevent DNA damage response and degradation. When telomeres become critically short, the DNA damage response is activated at chromosome ends which induces cellular senescence or apoptosis. Telomeres are protected by the double stranded DNA binding prot...

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Detalles Bibliográficos
Autores principales:	Lagunas, Angelica M., Wu, Jianchun, Crowe, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655185/ https://www.ncbi.nlm.nih.gov/pubmed/29113290 http://dx.doi.org/10.18632/oncotarget.20960

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