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Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients

Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient s...

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Autores principales: Zhang, Yan, Liu, Lingyan, Yin, Tai-Lang, Yang, Jing, Xiong, Cheng-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655213/
https://www.ncbi.nlm.nih.gov/pubmed/29113318
http://dx.doi.org/10.18632/oncotarget.19058
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author Zhang, Yan
Liu, Lingyan
Yin, Tai-Lang
Yang, Jing
Xiong, Cheng-Liang
author_facet Zhang, Yan
Liu, Lingyan
Yin, Tai-Lang
Yang, Jing
Xiong, Cheng-Liang
author_sort Zhang, Yan
collection PubMed
description Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls. Significant increases of glycoprotein, acetate, cholesterol, significant decreases of lactic acid, glutamine, pyruvate, and alanine, have been discovered in PCOS follicular fluids. Furthermore, the Pearson correlations analysis indicated significant relationship existed between ART results and NMR detected follicular metabolites. All these results indicated that PCOS may induce dyslipidemia, low-grade inflammation, and disorder of glycolysis, pyruvate and amino acid metabolism in follicular fluids.
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spelling pubmed-56552132017-11-06 Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients Zhang, Yan Liu, Lingyan Yin, Tai-Lang Yang, Jing Xiong, Cheng-Liang Oncotarget Research Paper Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls. Significant increases of glycoprotein, acetate, cholesterol, significant decreases of lactic acid, glutamine, pyruvate, and alanine, have been discovered in PCOS follicular fluids. Furthermore, the Pearson correlations analysis indicated significant relationship existed between ART results and NMR detected follicular metabolites. All these results indicated that PCOS may induce dyslipidemia, low-grade inflammation, and disorder of glycolysis, pyruvate and amino acid metabolism in follicular fluids. Impact Journals LLC 2017-07-06 /pmc/articles/PMC5655213/ /pubmed/29113318 http://dx.doi.org/10.18632/oncotarget.19058 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Zhang, Yan
Liu, Lingyan
Yin, Tai-Lang
Yang, Jing
Xiong, Cheng-Liang
Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title_full Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title_fullStr Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title_full_unstemmed Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title_short Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
title_sort follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655213/
https://www.ncbi.nlm.nih.gov/pubmed/29113318
http://dx.doi.org/10.18632/oncotarget.19058
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