Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis

Excessive skin scars due to elective operations or trauma represent a challenging clinical problem. Pathophysiology of hypertrophic scars entails a prolonged inflammatory and proliferative phase of wound healing. Over expression of TGF-β1 and COX-2 play key regulatory roles of the aberrant fibrogeni...

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Detalles Bibliográficos
Autores principales: Zhou, Jia, Zhao, Yixuan, Simonenko, Vera, Xu, John J., Liu, Kai, Wang, Deling, Shi, Jingli, Zhong, Tianyi, Zhang, Lixia, Zeng, Lun, Huang, Bin, Tang, Shenggao, Lu, Alan Y., Mixson, A. James, Sun, Yangbai, Lu, Patrick Y., Li, Qingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655228/
https://www.ncbi.nlm.nih.gov/pubmed/29113333
http://dx.doi.org/10.18632/oncotarget.20869

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