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High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies

D-dimer, one of the canonical markers of hypercoagulability, was reported to be a potential prognostic marker of colorectal cancer. However, an inconsistent conclusion existed in several published studies. Thus, we performed this meta-analysis to provide a comprehensive insight into the prognostic r...

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Autores principales: Lu, Shao-Long, Ye, Zhi-Hua, Ling, Tong, Liang, Si-Yuan, Li, Hui, Tang, Xiao-Zhun, Xu, Yan-Song, Tang, Wei-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655273/
https://www.ncbi.nlm.nih.gov/pubmed/29113378
http://dx.doi.org/10.18632/oncotarget.20919
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author Lu, Shao-Long
Ye, Zhi-Hua
Ling, Tong
Liang, Si-Yuan
Li, Hui
Tang, Xiao-Zhun
Xu, Yan-Song
Tang, Wei-Zhong
author_facet Lu, Shao-Long
Ye, Zhi-Hua
Ling, Tong
Liang, Si-Yuan
Li, Hui
Tang, Xiao-Zhun
Xu, Yan-Song
Tang, Wei-Zhong
author_sort Lu, Shao-Long
collection PubMed
description D-dimer, one of the canonical markers of hypercoagulability, was reported to be a potential prognostic marker of colorectal cancer. However, an inconsistent conclusion existed in several published studies. Thus, we performed this meta-analysis to provide a comprehensive insight into the prognostic role for pretreatment D-dimer in colorectal cancer. Six databases (English: Pubmed, Embase and Web of Science; Chinese: CNKI, Wangfang and VIP) were utilized for the literature retrieval. Hazard ratio (HR) was pooled by Stata 12.0. A total of fifteen studies (2283 cases) corresponded to this meta-analysis and provided available data to evaluate the prognostic role of D-dimer for colorectal cancer. The pooled HR reached 2.167 (95%. CI (confidence interval): 1.672–2.809, P < 0.001) utilizing random effect model due to obvious heterogeneity among the included studies (I(2): 73.3%; P < 0.001). To explore the heterogeneity among the studies, we conducted a sensitivity analysis and found a heterogeneous study. After removing it, the heterogeneity reduced substantially (I(2): 0%; P = 0.549) and we obtained a more convincing result by fixed effect model (HR = 2.143, 95% CI = 1.922–2.390, P < 0.001, 14 studies with 2179 cases). In summary, high pretreatment plasma D-dimer predicts poor survival of colorectal cancer based on the current evidence. Further prospective researches are necessary to confirm the role of D-dimer in colorectal cancer.
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spelling pubmed-56552732017-11-06 High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies Lu, Shao-Long Ye, Zhi-Hua Ling, Tong Liang, Si-Yuan Li, Hui Tang, Xiao-Zhun Xu, Yan-Song Tang, Wei-Zhong Oncotarget Meta-Analysis D-dimer, one of the canonical markers of hypercoagulability, was reported to be a potential prognostic marker of colorectal cancer. However, an inconsistent conclusion existed in several published studies. Thus, we performed this meta-analysis to provide a comprehensive insight into the prognostic role for pretreatment D-dimer in colorectal cancer. Six databases (English: Pubmed, Embase and Web of Science; Chinese: CNKI, Wangfang and VIP) were utilized for the literature retrieval. Hazard ratio (HR) was pooled by Stata 12.0. A total of fifteen studies (2283 cases) corresponded to this meta-analysis and provided available data to evaluate the prognostic role of D-dimer for colorectal cancer. The pooled HR reached 2.167 (95%. CI (confidence interval): 1.672–2.809, P < 0.001) utilizing random effect model due to obvious heterogeneity among the included studies (I(2): 73.3%; P < 0.001). To explore the heterogeneity among the studies, we conducted a sensitivity analysis and found a heterogeneous study. After removing it, the heterogeneity reduced substantially (I(2): 0%; P = 0.549) and we obtained a more convincing result by fixed effect model (HR = 2.143, 95% CI = 1.922–2.390, P < 0.001, 14 studies with 2179 cases). In summary, high pretreatment plasma D-dimer predicts poor survival of colorectal cancer based on the current evidence. Further prospective researches are necessary to confirm the role of D-dimer in colorectal cancer. Impact Journals LLC 2017-09-15 /pmc/articles/PMC5655273/ /pubmed/29113378 http://dx.doi.org/10.18632/oncotarget.20919 Text en Copyright: © 2017 Lu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Meta-Analysis
Lu, Shao-Long
Ye, Zhi-Hua
Ling, Tong
Liang, Si-Yuan
Li, Hui
Tang, Xiao-Zhun
Xu, Yan-Song
Tang, Wei-Zhong
High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title_full High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title_fullStr High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title_full_unstemmed High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title_short High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
title_sort high pretreatment plasma d-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655273/
https://www.ncbi.nlm.nih.gov/pubmed/29113378
http://dx.doi.org/10.18632/oncotarget.20919
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