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Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655292/ https://www.ncbi.nlm.nih.gov/pubmed/29113397 http://dx.doi.org/10.18632/oncotarget.18996 |
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author | Wang, Xixi Li, Junyi Yuan, Yongsheng Wang, Min Ding, Jian Zhang, Jiejin Zhu, Lin Shen, Yuting Zhang, Hui Zhang, Kezhong |
author_facet | Wang, Xixi Li, Junyi Yuan, Yongsheng Wang, Min Ding, Jian Zhang, Jiejin Zhu, Lin Shen, Yuting Zhang, Hui Zhang, Kezhong |
author_sort | Wang, Xixi |
collection | PubMed |
description | In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety. Decreased putamen FC with the orbitofrontal gyrus and cerebellum also correlated with increased anxiety in Parkinson's disease. Our findings demonstrate that anxiety disorder in Parkinson's disease is associated with abnormal putamen FC networks, especially with caudatum, orbitofrontal gyrus and cerebellum. |
format | Online Article Text |
id | pubmed-5655292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56552922017-11-06 Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease Wang, Xixi Li, Junyi Yuan, Yongsheng Wang, Min Ding, Jian Zhang, Jiejin Zhu, Lin Shen, Yuting Zhang, Hui Zhang, Kezhong Oncotarget Clinical Research Paper In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety. Decreased putamen FC with the orbitofrontal gyrus and cerebellum also correlated with increased anxiety in Parkinson's disease. Our findings demonstrate that anxiety disorder in Parkinson's disease is associated with abnormal putamen FC networks, especially with caudatum, orbitofrontal gyrus and cerebellum. Impact Journals LLC 2017-07-05 /pmc/articles/PMC5655292/ /pubmed/29113397 http://dx.doi.org/10.18632/oncotarget.18996 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Clinical Research Paper Wang, Xixi Li, Junyi Yuan, Yongsheng Wang, Min Ding, Jian Zhang, Jiejin Zhu, Lin Shen, Yuting Zhang, Hui Zhang, Kezhong Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title | Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title_full | Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title_fullStr | Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title_full_unstemmed | Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title_short | Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease |
title_sort | altered putamen functional connectivity is associated with anxiety disorder in parkinson's disease |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655292/ https://www.ncbi.nlm.nih.gov/pubmed/29113397 http://dx.doi.org/10.18632/oncotarget.18996 |
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