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A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer
OBJECTIVES: To investigate risk factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment. MATERIALS AND METHODS: A total of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655305/ https://www.ncbi.nlm.nih.gov/pubmed/29113410 http://dx.doi.org/10.18632/oncotarget.20828 |
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author | Xie, Xin-Sheng Lin, Jian-Xian Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lu, Jun Chen, Qi-Yue Cao, Long-Long Lin, Mi Tu, Ru-Hong Huang, Chang-Ming Zheng, Chao-Hui |
author_facet | Xie, Xin-Sheng Lin, Jian-Xian Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lu, Jun Chen, Qi-Yue Cao, Long-Long Lin, Mi Tu, Ru-Hong Huang, Chang-Ming Zheng, Chao-Hui |
author_sort | Xie, Xin-Sheng |
collection | PubMed |
description | OBJECTIVES: To investigate risk factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment. MATERIALS AND METHODS: A total of 1789 PGC patients were enrolled in our study. We analyzed the risk factors of PH and constructed a scoring system using 75% of the cases as the experimental group and 25% of the cases as a verification group to demonstrate the effectiveness. RESULTS: Among these 1789 patients, 46 (2.6%) developed PH. Univariate and multivariate analysis in the experimental group indicated that having more than 41 lymph node excisions, combined organ resection, stage III tumor and postoperative digestive fistula were independent risk factors of PH. According to the independent risk factors, we constructed a scoring system to separate patients into low-risk (0–2 points) and high-risk (≥ 3 points) groups. The area under the ROC curve for this scoring system was 0.748. In the verification group, the risk of PH predicted by the scoring system was not significantly different from the actual incidence observed. CONCLUSIONS: This scoring system could simply and effectively predict the occurrence of PH following LARG with D2 lymphadenectomy for PGC. The predictive system will help surgeons evaluate risk and select risk-adapted interventions to improve surgical safety. |
format | Online Article Text |
id | pubmed-5655305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56553052017-11-06 A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer Xie, Xin-Sheng Lin, Jian-Xian Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lu, Jun Chen, Qi-Yue Cao, Long-Long Lin, Mi Tu, Ru-Hong Huang, Chang-Ming Zheng, Chao-Hui Oncotarget Clinical Research Paper OBJECTIVES: To investigate risk factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment. MATERIALS AND METHODS: A total of 1789 PGC patients were enrolled in our study. We analyzed the risk factors of PH and constructed a scoring system using 75% of the cases as the experimental group and 25% of the cases as a verification group to demonstrate the effectiveness. RESULTS: Among these 1789 patients, 46 (2.6%) developed PH. Univariate and multivariate analysis in the experimental group indicated that having more than 41 lymph node excisions, combined organ resection, stage III tumor and postoperative digestive fistula were independent risk factors of PH. According to the independent risk factors, we constructed a scoring system to separate patients into low-risk (0–2 points) and high-risk (≥ 3 points) groups. The area under the ROC curve for this scoring system was 0.748. In the verification group, the risk of PH predicted by the scoring system was not significantly different from the actual incidence observed. CONCLUSIONS: This scoring system could simply and effectively predict the occurrence of PH following LARG with D2 lymphadenectomy for PGC. The predictive system will help surgeons evaluate risk and select risk-adapted interventions to improve surgical safety. Impact Journals LLC 2017-09-11 /pmc/articles/PMC5655305/ /pubmed/29113410 http://dx.doi.org/10.18632/oncotarget.20828 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Clinical Research Paper Xie, Xin-Sheng Lin, Jian-Xian Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lu, Jun Chen, Qi-Yue Cao, Long-Long Lin, Mi Tu, Ru-Hong Huang, Chang-Ming Zheng, Chao-Hui A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title | A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title_full | A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title_fullStr | A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title_full_unstemmed | A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title_short | A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer |
title_sort | risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with d2 lymphadenectomy for primary gastric cancer |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655305/ https://www.ncbi.nlm.nih.gov/pubmed/29113410 http://dx.doi.org/10.18632/oncotarget.20828 |
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