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Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine

Inclusion internal mammary lymph nodes as a part of regional nodal irradiation have a potential to reduce local recurrence, distant recurrence, and improve survival in breast cancer. However, the increased risk of cardiac toxicity and lungs injure associated with internal mammary lymph nodes irradia...

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Autores principales: Cong, Bin-Bin, Cao, Xiao-Shan, Cao, Lu, Zhu, Hui, Yu, Yi-Shan, Yu, Jin-Ming, Wang, Yong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655311/
https://www.ncbi.nlm.nih.gov/pubmed/29113416
http://dx.doi.org/10.18632/oncotarget.20186
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author Cong, Bin-Bin
Cao, Xiao-Shan
Cao, Lu
Zhu, Hui
Yu, Yi-Shan
Yu, Jin-Ming
Wang, Yong-Sheng
author_facet Cong, Bin-Bin
Cao, Xiao-Shan
Cao, Lu
Zhu, Hui
Yu, Yi-Shan
Yu, Jin-Ming
Wang, Yong-Sheng
author_sort Cong, Bin-Bin
collection PubMed
description Inclusion internal mammary lymph nodes as a part of regional nodal irradiation have a potential to reduce local recurrence, distant recurrence, and improve survival in breast cancer. However, the increased risk of cardiac toxicity and lungs injure associated with internal mammary lymph nodes irradiation has drew more and more attention. Estimating risk of metastasis in internal mammary lymph nodes based on axillary lymph nodes metastasis status is not always reliable: low-risk do not always mean negative in internal mammary lymph nodes and high-risk do not always indicate positive in internal mammary lymph nodes. Inaccurate prediction of in internal mammary lymph nodes metastasis might lead to over- or under-treatment of in internal mammary lymph node. Internal mammary sentinel lymph node biopsy is a minimally invasive technique which has a high potential to accurately evaluate the metastasis status in in internal mammary lymph nodes and improve accuracy of nodal staging. This technique might be a useful tool to guide individualized internal mammary lymph nodes irradiation.
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spelling pubmed-56553112017-11-06 Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine Cong, Bin-Bin Cao, Xiao-Shan Cao, Lu Zhu, Hui Yu, Yi-Shan Yu, Jin-Ming Wang, Yong-Sheng Oncotarget Review Inclusion internal mammary lymph nodes as a part of regional nodal irradiation have a potential to reduce local recurrence, distant recurrence, and improve survival in breast cancer. However, the increased risk of cardiac toxicity and lungs injure associated with internal mammary lymph nodes irradiation has drew more and more attention. Estimating risk of metastasis in internal mammary lymph nodes based on axillary lymph nodes metastasis status is not always reliable: low-risk do not always mean negative in internal mammary lymph nodes and high-risk do not always indicate positive in internal mammary lymph nodes. Inaccurate prediction of in internal mammary lymph nodes metastasis might lead to over- or under-treatment of in internal mammary lymph node. Internal mammary sentinel lymph node biopsy is a minimally invasive technique which has a high potential to accurately evaluate the metastasis status in in internal mammary lymph nodes and improve accuracy of nodal staging. This technique might be a useful tool to guide individualized internal mammary lymph nodes irradiation. Impact Journals LLC 2017-08-11 /pmc/articles/PMC5655311/ /pubmed/29113416 http://dx.doi.org/10.18632/oncotarget.20186 Text en Copyright: © 2017 Cong et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Cong, Bin-Bin
Cao, Xiao-Shan
Cao, Lu
Zhu, Hui
Yu, Yi-Shan
Yu, Jin-Ming
Wang, Yong-Sheng
Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title_full Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title_fullStr Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title_full_unstemmed Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title_short Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
title_sort internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655311/
https://www.ncbi.nlm.nih.gov/pubmed/29113416
http://dx.doi.org/10.18632/oncotarget.20186
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