Role of growth differentiation factor 11 in development, physiology and disease

Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes. Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as emb...

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Detalles Bibliográficos
Autores principales: Zhang, Yonghui, Wei, Yong, Liu, Dan, Liu, Feng, Li, Xiaoshan, Pan, Lianhong, Pang, Yi, Chen, Dilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655313/
https://www.ncbi.nlm.nih.gov/pubmed/29113418
http://dx.doi.org/10.18632/oncotarget.20258
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author Zhang, Yonghui
Wei, Yong
Liu, Dan
Liu, Feng
Li, Xiaoshan
Pan, Lianhong
Pang, Yi
Chen, Dilong
author_facet Zhang, Yonghui
Wei, Yong
Liu, Dan
Liu, Feng
Li, Xiaoshan
Pan, Lianhong
Pang, Yi
Chen, Dilong
author_sort Zhang, Yonghui
collection PubMed
description Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes. Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer. In addition, there are contradictory reports regarding the role of GDF11 in aging, cardiovascular disease, diabetes mellitus, osteogenesis, skeletal muscle development, and neurogenesis. In this review, we describe the GDF11 signaling pathway and its potential role in development, physiology and disease.
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spelling pubmed-56553132017-11-06 Role of growth differentiation factor 11 in development, physiology and disease Zhang, Yonghui Wei, Yong Liu, Dan Liu, Feng Li, Xiaoshan Pan, Lianhong Pang, Yi Chen, Dilong Oncotarget Review Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes. Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer. In addition, there are contradictory reports regarding the role of GDF11 in aging, cardiovascular disease, diabetes mellitus, osteogenesis, skeletal muscle development, and neurogenesis. In this review, we describe the GDF11 signaling pathway and its potential role in development, physiology and disease. Impact Journals LLC 2017-08-14 /pmc/articles/PMC5655313/ /pubmed/29113418 http://dx.doi.org/10.18632/oncotarget.20258 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Zhang, Yonghui
Wei, Yong
Liu, Dan
Liu, Feng
Li, Xiaoshan
Pan, Lianhong
Pang, Yi
Chen, Dilong
Role of growth differentiation factor 11 in development, physiology and disease
title Role of growth differentiation factor 11 in development, physiology and disease
title_full Role of growth differentiation factor 11 in development, physiology and disease
title_fullStr Role of growth differentiation factor 11 in development, physiology and disease
title_full_unstemmed Role of growth differentiation factor 11 in development, physiology and disease
title_short Role of growth differentiation factor 11 in development, physiology and disease
title_sort role of growth differentiation factor 11 in development, physiology and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655313/
https://www.ncbi.nlm.nih.gov/pubmed/29113418
http://dx.doi.org/10.18632/oncotarget.20258
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