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Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit f...

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Autores principales: Ding, Ai-Jun, Zheng, Shan-Qing, Huang, Xiao-Bing, Xing, Ti-Kun, Wu, Gui-Sheng, Sun, Hua-Ying, Qi, Shu-Hua, Luo, Huai-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655361/
https://www.ncbi.nlm.nih.gov/pubmed/28567542
http://dx.doi.org/10.1007/s13659-017-0135-9
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author Ding, Ai-Jun
Zheng, Shan-Qing
Huang, Xiao-Bing
Xing, Ti-Kun
Wu, Gui-Sheng
Sun, Hua-Ying
Qi, Shu-Hua
Luo, Huai-Rong
author_facet Ding, Ai-Jun
Zheng, Shan-Qing
Huang, Xiao-Bing
Xing, Ti-Kun
Wu, Gui-Sheng
Sun, Hua-Ying
Qi, Shu-Hua
Luo, Huai-Rong
author_sort Ding, Ai-Jun
collection PubMed
description Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products.
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spelling pubmed-56553612017-11-06 Current Perspective in the Discovery of Anti-aging Agents from Natural Products Ding, Ai-Jun Zheng, Shan-Qing Huang, Xiao-Bing Xing, Ti-Kun Wu, Gui-Sheng Sun, Hua-Ying Qi, Shu-Hua Luo, Huai-Rong Nat Prod Bioprospect Review Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products. Springer Singapore 2017-05-31 /pmc/articles/PMC5655361/ /pubmed/28567542 http://dx.doi.org/10.1007/s13659-017-0135-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Ding, Ai-Jun
Zheng, Shan-Qing
Huang, Xiao-Bing
Xing, Ti-Kun
Wu, Gui-Sheng
Sun, Hua-Ying
Qi, Shu-Hua
Luo, Huai-Rong
Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title_full Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title_fullStr Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title_full_unstemmed Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title_short Current Perspective in the Discovery of Anti-aging Agents from Natural Products
title_sort current perspective in the discovery of anti-aging agents from natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655361/
https://www.ncbi.nlm.nih.gov/pubmed/28567542
http://dx.doi.org/10.1007/s13659-017-0135-9
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