Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jinyu, Zhao, Weibo, Chen, Haixiao, Qin, An, Zhu, Peizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655378/
https://www.ncbi.nlm.nih.gov/pubmed/29067569
http://dx.doi.org/10.1186/s11671-017-2324-1
_version_ 1783273522359959552
author Wang, Jinyu
Zhao, Weibo
Chen, Haixiao
Qin, An
Zhu, Peizhi
author_facet Wang, Jinyu
Zhao, Weibo
Chen, Haixiao
Qin, An
Zhu, Peizhi
author_sort Wang, Jinyu
collection PubMed
description Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.
format Online
Article
Text
id pubmed-5655378
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-56553782017-11-06 Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels Wang, Jinyu Zhao, Weibo Chen, Haixiao Qin, An Zhu, Peizhi Nanoscale Res Lett Nano Express Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues. Springer US 2017-10-24 /pmc/articles/PMC5655378/ /pubmed/29067569 http://dx.doi.org/10.1186/s11671-017-2324-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Wang, Jinyu
Zhao, Weibo
Chen, Haixiao
Qin, An
Zhu, Peizhi
Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title_full Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title_fullStr Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title_full_unstemmed Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title_short Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
title_sort anti-tumor study of chondroitin sulfate-methotrexate nanogels
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655378/
https://www.ncbi.nlm.nih.gov/pubmed/29067569
http://dx.doi.org/10.1186/s11671-017-2324-1
work_keys_str_mv AT wangjinyu antitumorstudyofchondroitinsulfatemethotrexatenanogels
AT zhaoweibo antitumorstudyofchondroitinsulfatemethotrexatenanogels
AT chenhaixiao antitumorstudyofchondroitinsulfatemethotrexatenanogels
AT qinan antitumorstudyofchondroitinsulfatemethotrexatenanogels
AT zhupeizhi antitumorstudyofchondroitinsulfatemethotrexatenanogels

Ejemplares similares