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Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease

Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been implicated in AD pathogenesis. However, it is unclear whether ROS contributes to synaptic dysfunction seen in AD patho...

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Detalles Bibliográficos
Autores principales:	Ahmad, Faraz, Singh, Kunal, Das, Debajyoti, Gowaikar, Ruturaj, Shaw, Eisha, Ramachandran, Arathy, Rupanagudi, Khader Valli, Kommaddi, Reddy Peera, Bennett, David A., Ravindranath, Vijayalakshmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2017
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655421/ https://www.ncbi.nlm.nih.gov/pubmed/28264587 http://dx.doi.org/10.1089/ars.2016.6860

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