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Substantial vertebral body osteophytes protect against severe vertebral fractures in compression

Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three v...

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Autores principales: Wagnac, Eric, Aubin, Carl-Éric, Chaumoître, Kathia, Mac-Thiong, Jean-Marc, Ménard, Anne-Laure, Petit, Yvan, Garo, Anaïs, Arnoux, Pierre-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655488/
https://www.ncbi.nlm.nih.gov/pubmed/29065144
http://dx.doi.org/10.1371/journal.pone.0186779
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author Wagnac, Eric
Aubin, Carl-Éric
Chaumoître, Kathia
Mac-Thiong, Jean-Marc
Ménard, Anne-Laure
Petit, Yvan
Garo, Anaïs
Arnoux, Pierre-Jean
author_facet Wagnac, Eric
Aubin, Carl-Éric
Chaumoître, Kathia
Mac-Thiong, Jean-Marc
Ménard, Anne-Laure
Petit, Yvan
Garo, Anaïs
Arnoux, Pierre-Jean
author_sort Wagnac, Eric
collection PubMed
description Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three vertebrae (from T5-T7 to T11-L1) and their surrounding soft tissues were harvested from nine cadavers, aged 77 to 92 years. Specimens were imaged using quantitative computer tomography (QCT) for medical observation, classification of the intervertebral disc degeneration (Thomson grade) and measurement of the vertebral trabecular density (VTD), height and cross-sectional area. Specimens were divided into two groups (with (n = 9) or without (n = 8) substantial vertebral body osteophytes) and compressed axially at a dynamic displacement rate of 1 m/s, up to failure. Normalized force-displacement curves, videos and QCT images allowed characterizing failure parameters (force, displacement and energy at failure) and fracture patterns. Results were analyzed using chi-squared tests for sampling distributions and linear regression for correlations between VTD and failure parameters. Specimens with substantial vertebral body osteophytes present higher stiffness (2.7 times on average) and force at failure (1.8 times on average) than other segments. The presence of osteophytes significantly influences the location, pattern and type of fracture. VTD was a good predictor of the dynamic force and energy at failure for specimens without substantial osteophytes. This study also showed that vertebral body osteophytes provide a protective mechanism to the underlying vertebra against severe compression fractures.
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spelling pubmed-56554882017-11-09 Substantial vertebral body osteophytes protect against severe vertebral fractures in compression Wagnac, Eric Aubin, Carl-Éric Chaumoître, Kathia Mac-Thiong, Jean-Marc Ménard, Anne-Laure Petit, Yvan Garo, Anaïs Arnoux, Pierre-Jean PLoS One Research Article Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three vertebrae (from T5-T7 to T11-L1) and their surrounding soft tissues were harvested from nine cadavers, aged 77 to 92 years. Specimens were imaged using quantitative computer tomography (QCT) for medical observation, classification of the intervertebral disc degeneration (Thomson grade) and measurement of the vertebral trabecular density (VTD), height and cross-sectional area. Specimens were divided into two groups (with (n = 9) or without (n = 8) substantial vertebral body osteophytes) and compressed axially at a dynamic displacement rate of 1 m/s, up to failure. Normalized force-displacement curves, videos and QCT images allowed characterizing failure parameters (force, displacement and energy at failure) and fracture patterns. Results were analyzed using chi-squared tests for sampling distributions and linear regression for correlations between VTD and failure parameters. Specimens with substantial vertebral body osteophytes present higher stiffness (2.7 times on average) and force at failure (1.8 times on average) than other segments. The presence of osteophytes significantly influences the location, pattern and type of fracture. VTD was a good predictor of the dynamic force and energy at failure for specimens without substantial osteophytes. This study also showed that vertebral body osteophytes provide a protective mechanism to the underlying vertebra against severe compression fractures. Public Library of Science 2017-10-24 /pmc/articles/PMC5655488/ /pubmed/29065144 http://dx.doi.org/10.1371/journal.pone.0186779 Text en © 2017 Wagnac et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wagnac, Eric
Aubin, Carl-Éric
Chaumoître, Kathia
Mac-Thiong, Jean-Marc
Ménard, Anne-Laure
Petit, Yvan
Garo, Anaïs
Arnoux, Pierre-Jean
Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title_full Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title_fullStr Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title_full_unstemmed Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title_short Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
title_sort substantial vertebral body osteophytes protect against severe vertebral fractures in compression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655488/
https://www.ncbi.nlm.nih.gov/pubmed/29065144
http://dx.doi.org/10.1371/journal.pone.0186779
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