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Substantial vertebral body osteophytes protect against severe vertebral fractures in compression
Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three v...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655488/ https://www.ncbi.nlm.nih.gov/pubmed/29065144 http://dx.doi.org/10.1371/journal.pone.0186779 |
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author | Wagnac, Eric Aubin, Carl-Éric Chaumoître, Kathia Mac-Thiong, Jean-Marc Ménard, Anne-Laure Petit, Yvan Garo, Anaïs Arnoux, Pierre-Jean |
author_facet | Wagnac, Eric Aubin, Carl-Éric Chaumoître, Kathia Mac-Thiong, Jean-Marc Ménard, Anne-Laure Petit, Yvan Garo, Anaïs Arnoux, Pierre-Jean |
author_sort | Wagnac, Eric |
collection | PubMed |
description | Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three vertebrae (from T5-T7 to T11-L1) and their surrounding soft tissues were harvested from nine cadavers, aged 77 to 92 years. Specimens were imaged using quantitative computer tomography (QCT) for medical observation, classification of the intervertebral disc degeneration (Thomson grade) and measurement of the vertebral trabecular density (VTD), height and cross-sectional area. Specimens were divided into two groups (with (n = 9) or without (n = 8) substantial vertebral body osteophytes) and compressed axially at a dynamic displacement rate of 1 m/s, up to failure. Normalized force-displacement curves, videos and QCT images allowed characterizing failure parameters (force, displacement and energy at failure) and fracture patterns. Results were analyzed using chi-squared tests for sampling distributions and linear regression for correlations between VTD and failure parameters. Specimens with substantial vertebral body osteophytes present higher stiffness (2.7 times on average) and force at failure (1.8 times on average) than other segments. The presence of osteophytes significantly influences the location, pattern and type of fracture. VTD was a good predictor of the dynamic force and energy at failure for specimens without substantial osteophytes. This study also showed that vertebral body osteophytes provide a protective mechanism to the underlying vertebra against severe compression fractures. |
format | Online Article Text |
id | pubmed-5655488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56554882017-11-09 Substantial vertebral body osteophytes protect against severe vertebral fractures in compression Wagnac, Eric Aubin, Carl-Éric Chaumoître, Kathia Mac-Thiong, Jean-Marc Ménard, Anne-Laure Petit, Yvan Garo, Anaïs Arnoux, Pierre-Jean PLoS One Research Article Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three vertebrae (from T5-T7 to T11-L1) and their surrounding soft tissues were harvested from nine cadavers, aged 77 to 92 years. Specimens were imaged using quantitative computer tomography (QCT) for medical observation, classification of the intervertebral disc degeneration (Thomson grade) and measurement of the vertebral trabecular density (VTD), height and cross-sectional area. Specimens were divided into two groups (with (n = 9) or without (n = 8) substantial vertebral body osteophytes) and compressed axially at a dynamic displacement rate of 1 m/s, up to failure. Normalized force-displacement curves, videos and QCT images allowed characterizing failure parameters (force, displacement and energy at failure) and fracture patterns. Results were analyzed using chi-squared tests for sampling distributions and linear regression for correlations between VTD and failure parameters. Specimens with substantial vertebral body osteophytes present higher stiffness (2.7 times on average) and force at failure (1.8 times on average) than other segments. The presence of osteophytes significantly influences the location, pattern and type of fracture. VTD was a good predictor of the dynamic force and energy at failure for specimens without substantial osteophytes. This study also showed that vertebral body osteophytes provide a protective mechanism to the underlying vertebra against severe compression fractures. Public Library of Science 2017-10-24 /pmc/articles/PMC5655488/ /pubmed/29065144 http://dx.doi.org/10.1371/journal.pone.0186779 Text en © 2017 Wagnac et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Wagnac, Eric Aubin, Carl-Éric Chaumoître, Kathia Mac-Thiong, Jean-Marc Ménard, Anne-Laure Petit, Yvan Garo, Anaïs Arnoux, Pierre-Jean Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title | Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title_full | Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title_fullStr | Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title_full_unstemmed | Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title_short | Substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
title_sort | substantial vertebral body osteophytes protect against severe vertebral fractures in compression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655488/ https://www.ncbi.nlm.nih.gov/pubmed/29065144 http://dx.doi.org/10.1371/journal.pone.0186779 |
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