Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children

Acute kidney injury (AKI) is common in children admitted to hospital. Whilst some recover normal kidney function following an acute kidney insult, a significant proportion experience long-term sequelae. The aim of this review is to summarize current understanding of the processes that can lead to se...

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Autor principal: Hayes, Wesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Educational Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655580/
https://www.ncbi.nlm.nih.gov/pubmed/28197888
http://dx.doi.org/10.1007/s00467-017-3598-3
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author Hayes, Wesley
author_facet Hayes, Wesley
author_sort Hayes, Wesley
collection PubMed
description Acute kidney injury (AKI) is common in children admitted to hospital. Whilst some recover normal kidney function following an acute kidney insult, a significant proportion experience long-term sequelae. The aim of this review is to summarize current understanding of the processes that can lead to sequelae following AKI. Kidney injury, repair, recovery and progression are described. Risk factors for progression are outlined, and potential strategies to stratify the risk of progression in children with AKI are discussed. Clinical management priorities to minimize sequelae are suggested. Looking ahead, novel therapeutic targets are discussed with the potential to accelerate adaptive repair and ameliorate the progression and sequelae of AKI in the future.
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spelling pubmed-56555802017-11-01 Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children Hayes, Wesley Pediatr Nephrol Educational Review Acute kidney injury (AKI) is common in children admitted to hospital. Whilst some recover normal kidney function following an acute kidney insult, a significant proportion experience long-term sequelae. The aim of this review is to summarize current understanding of the processes that can lead to sequelae following AKI. Kidney injury, repair, recovery and progression are described. Risk factors for progression are outlined, and potential strategies to stratify the risk of progression in children with AKI are discussed. Clinical management priorities to minimize sequelae are suggested. Looking ahead, novel therapeutic targets are discussed with the potential to accelerate adaptive repair and ameliorate the progression and sequelae of AKI in the future. Springer Berlin Heidelberg 2017-02-15 2017 /pmc/articles/PMC5655580/ /pubmed/28197888 http://dx.doi.org/10.1007/s00467-017-3598-3 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Educational Review
Hayes, Wesley
Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title_full Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title_fullStr Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title_full_unstemmed Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title_short Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
title_sort stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655580/
https://www.ncbi.nlm.nih.gov/pubmed/28197888
http://dx.doi.org/10.1007/s00467-017-3598-3
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