Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR

The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is propos...

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Autores principales: Degryse, Bernard, Britto, Mishan, Shan, Chun Xu, Wallace, Robert G., Rochfort, Keith D., Cummins, Philip M., Meade, Gerardene, Murphy, Ronan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Cell biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655590/
https://www.ncbi.nlm.nih.gov/pubmed/29085875
http://dx.doi.org/10.1016/j.dib.2017.10.023
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author Degryse, Bernard
Britto, Mishan
Shan, Chun Xu
Wallace, Robert G.
Rochfort, Keith D.
Cummins, Philip M.
Meade, Gerardene
Murphy, Ronan P.
author_facet Degryse, Bernard
Britto, Mishan
Shan, Chun Xu
Wallace, Robert G.
Rochfort, Keith D.
Cummins, Philip M.
Meade, Gerardene
Murphy, Ronan P.
author_sort Degryse, Bernard
collection PubMed
description The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.
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spelling pubmed-56555902017-10-30 Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR Degryse, Bernard Britto, Mishan Shan, Chun Xu Wallace, Robert G. Rochfort, Keith D. Cummins, Philip M. Meade, Gerardene Murphy, Ronan P. Data Brief Cell biology The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively. Elsevier 2017-10-16 /pmc/articles/PMC5655590/ /pubmed/29085875 http://dx.doi.org/10.1016/j.dib.2017.10.023 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Cell biology
Degryse, Bernard
Britto, Mishan
Shan, Chun Xu
Wallace, Robert G.
Rochfort, Keith D.
Cummins, Philip M.
Meade, Gerardene
Murphy, Ronan P.
Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title_full Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title_fullStr Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title_full_unstemmed Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title_short Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
title_sort data on the regulation of moesin and merlin by the urokinase receptor (upar): model explaining distal activation of integrins by upar
topic Cell biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655590/
https://www.ncbi.nlm.nih.gov/pubmed/29085875
http://dx.doi.org/10.1016/j.dib.2017.10.023
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