Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

BACKGROUND: Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein. Increasing the levels of the dystrophin-related-protein utrophin is a highly promising therapy for DMD and has been shown to improve pa...

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Detalles Bibliográficos
Autores principales: Kennedy, Tahnee L., Moir, Lee, Hemming, Sarah, Edwards, Ben, Squire, Sarah, Davies, Kay, Guiraud, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655821/
https://www.ncbi.nlm.nih.gov/pubmed/29065908
http://dx.doi.org/10.1186/s13395-017-0139-5

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