RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with the general assumption that alterations in the transcriptome correlate with p...

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Detalles Bibliográficos
Autores principales: Pacheco, Natasha L., Heaven, Michael R., Holt, Leanne M., Crossman, David K., Boggio, Kristin J., Shaffer, Scott A., Flint, Daniel L., Olsen, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655833/
https://www.ncbi.nlm.nih.gov/pubmed/29090078
http://dx.doi.org/10.1186/s13229-017-0174-4

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