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Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

BACKGROUND: The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). METHODS: A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and...

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Autores principales: Gensous, Noémie, Marti, Aurélie, Barnetche, Thomas, Blanco, Patrick, Lazaro, Estibaliz, Seneschal, Julien, Truchetet, Marie-Elise, Duffau, Pierre, Richez, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655881/
https://www.ncbi.nlm.nih.gov/pubmed/29065901
http://dx.doi.org/10.1186/s13075-017-1442-6
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author Gensous, Noémie
Marti, Aurélie
Barnetche, Thomas
Blanco, Patrick
Lazaro, Estibaliz
Seneschal, Julien
Truchetet, Marie-Elise
Duffau, Pierre
Richez, Christophe
author_facet Gensous, Noémie
Marti, Aurélie
Barnetche, Thomas
Blanco, Patrick
Lazaro, Estibaliz
Seneschal, Julien
Truchetet, Marie-Elise
Duffau, Pierre
Richez, Christophe
author_sort Gensous, Noémie
collection PubMed
description BACKGROUND: The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). METHODS: A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire. Reports addressing the relationships between one or more defined biological test(s) and the occurrence of disease exacerbation were included in the systematic review. RESULTS: From all of the databases, 4668 records were retrieved, of which 69 studies or congress abstracts were selected for the systematic review. The performance of seven types of biomarkers performed routinely in clinical practice and nine types of novel biological markers was evaluated. Despite some encouraging results for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the others as a potential gold standard for flare prediction. The results were heterogeneous, and a lack of standardized data prevented us from identifying a powerful biomarker. CONCLUSIONS: No powerful conclusions could be drawn from this systematic review due to a lack of standardized data. Efforts should be undertaken to optimize future research on potential SLE biomarkers to develop validated candidates. Thus, we propose a standardized pattern for future studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13075-017-1442-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-56558812017-10-31 Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review Gensous, Noémie Marti, Aurélie Barnetche, Thomas Blanco, Patrick Lazaro, Estibaliz Seneschal, Julien Truchetet, Marie-Elise Duffau, Pierre Richez, Christophe Arthritis Res Ther Research Article BACKGROUND: The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). METHODS: A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire. Reports addressing the relationships between one or more defined biological test(s) and the occurrence of disease exacerbation were included in the systematic review. RESULTS: From all of the databases, 4668 records were retrieved, of which 69 studies or congress abstracts were selected for the systematic review. The performance of seven types of biomarkers performed routinely in clinical practice and nine types of novel biological markers was evaluated. Despite some encouraging results for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the others as a potential gold standard for flare prediction. The results were heterogeneous, and a lack of standardized data prevented us from identifying a powerful biomarker. CONCLUSIONS: No powerful conclusions could be drawn from this systematic review due to a lack of standardized data. Efforts should be undertaken to optimize future research on potential SLE biomarkers to develop validated candidates. Thus, we propose a standardized pattern for future studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13075-017-1442-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-10-24 2017 /pmc/articles/PMC5655881/ /pubmed/29065901 http://dx.doi.org/10.1186/s13075-017-1442-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gensous, Noémie
Marti, Aurélie
Barnetche, Thomas
Blanco, Patrick
Lazaro, Estibaliz
Seneschal, Julien
Truchetet, Marie-Elise
Duffau, Pierre
Richez, Christophe
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title_full Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title_fullStr Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title_full_unstemmed Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title_short Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
title_sort predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655881/
https://www.ncbi.nlm.nih.gov/pubmed/29065901
http://dx.doi.org/10.1186/s13075-017-1442-6
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