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α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and often poorly tolerated. We report tha...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656064/ https://www.ncbi.nlm.nih.gov/pubmed/28165480 http://dx.doi.org/10.1038/nm.4280 |
| _version_ | 1783273649214586880 |
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| author | Zee, Tiffany Bose, Neelanjan Zee, Jarcy Beck, Jennifer N. Yang, See Parihar, Jaspreet Yang, Min Damodar, Sruthi Hall, David O’Leary, Monique N. Ramanathan, Arvind Gerona, Roy R. Killilea, David W. Chi, Thomas Tischfield, Jay Sahota, Amrik Kahn, Arnold Stoller, Marshall L. Kapahi, Pankaj |
| author_facet | Zee, Tiffany Bose, Neelanjan Zee, Jarcy Beck, Jennifer N. Yang, See Parihar, Jaspreet Yang, Min Damodar, Sruthi Hall, David O’Leary, Monique N. Ramanathan, Arvind Gerona, Roy R. Killilea, David W. Chi, Thomas Tischfield, Jay Sahota, Amrik Kahn, Arnold Stoller, Marshall L. Kapahi, Pankaj |
| author_sort | Zee, Tiffany |
| collection | PubMed |
| description | Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria. |
| format | Online Article Text |
| id | pubmed-5656064 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56560642017-10-25 α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria Zee, Tiffany Bose, Neelanjan Zee, Jarcy Beck, Jennifer N. Yang, See Parihar, Jaspreet Yang, Min Damodar, Sruthi Hall, David O’Leary, Monique N. Ramanathan, Arvind Gerona, Roy R. Killilea, David W. Chi, Thomas Tischfield, Jay Sahota, Amrik Kahn, Arnold Stoller, Marshall L. Kapahi, Pankaj Nat Med Article Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria. 2017-02-06 2017-03 /pmc/articles/PMC5656064/ /pubmed/28165480 http://dx.doi.org/10.1038/nm.4280 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Zee, Tiffany Bose, Neelanjan Zee, Jarcy Beck, Jennifer N. Yang, See Parihar, Jaspreet Yang, Min Damodar, Sruthi Hall, David O’Leary, Monique N. Ramanathan, Arvind Gerona, Roy R. Killilea, David W. Chi, Thomas Tischfield, Jay Sahota, Amrik Kahn, Arnold Stoller, Marshall L. Kapahi, Pankaj α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title_full | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title_fullStr | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title_full_unstemmed | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title_short | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| title_sort | α-lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656064/ https://www.ncbi.nlm.nih.gov/pubmed/28165480 http://dx.doi.org/10.1038/nm.4280 |
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