Cargando…

Randomised controlled trial of two sequential artemisinin-based combination therapy regimens to treat uncomplicated falciparum malaria in African children: a protocol to investigate safety, efficacy and adherence

BACKGROUND: Management of uncomplicated Plasmodium falciparum malaria relies on artemisinin-based combination therapies (ACTs). These highly effective regimens have contributed to reductions in malaria morbidity and mortality. However, artemisinin resistance in Asia and changing parasite susceptibil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schallig, Henk DFH, Tinto, Halidou, Sawa, Patrick, Kaur, Harparkash, Duparc, Stephan, Ishengoma, Deus S, Magnussen, Pascal, Alifrangis, Michael, Sutherland, Colin J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656137/ https://www.ncbi.nlm.nih.gov/pubmed/29082016 http://dx.doi.org/10.1136/bmjgh-2017-000371

Ejemplares similares

A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya
por: Mens, Petra F, et al.
Publicado: (2008)

Residual Plasmodium falciparum Parasitemia in Kenyan Children After Artemisinin-Combination Therapy Is Associated With Increased Transmission to Mosquitoes and Parasite Recurrence
por: Beshir, Khalid B., et al.
Publicado: (2013)

Monitoring of efficacy and safety of artemisinin-based anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania
por: Shayo, Alex, et al.
Publicado: (2015)

Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana
por: Ahorhorlu, Samuel Yao, et al.
Publicado: (2023)

Artemisinin‐naphthoquine for treating uncomplicated Plasmodium falciparum malaria
por: Isba, Rachel, et al.
Publicado: (2015)

Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon
por: Whegang, Solange Youdom, et al.
Publicado: (2010)

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
por: Smithuis, Frank, et al.
Publicado: (2010)

Therapeutic efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in North-Eastern Tanzania
por: Shayo, Alex, et al.
Publicado: (2014)

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia
por: Osorio, Lyda, et al.
Publicado: (2007)

Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar
por: Ménard, Didier, et al.
Publicado: (2007)

Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges
por: Ishengoma, Deus S., et al.
Publicado: (2019)

In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso
por: Lingani, Moussa, et al.
Publicado: (2020)

Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated Plasmodium falciparum Malaria
por: Kurth, Florian, et al.
Publicado: (2016)

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)
por: Tiono, Alfred B, et al.
Publicado: (2015)

Open-label trial of three dosage regimens of fixed-dose combination of artemisinin and naphthoquine for treating uncomplicated falciparum malaria in calabar, Nigeria
por: Meremikwu, Martin M, et al.
Publicado: (2012)

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria
por: Ouologuem, Dinkorma T., et al.
Publicado: (2018)

Extended malaria parasite clearance time in African children following artemisinin-combination therapy enhances transmission to Anopheles mosquitoes
por: Beshir, Khalid B, et al.
Publicado: (2012)

Pyronaridine–artesunate and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial
por: Roth, Johanna M., et al.
Publicado: (2018)

A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan
por: Adam, Ishag, et al.
Publicado: (2006)

Efficacy of three artemisinin combination therapies for the treatmentof uncomplicated Plasmodium falciparum malaria in the Republic of Congo
por: van den Broek, Ingrid, et al.
Publicado: (2006)

Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children
por: Sowunmi, Akintunde, et al.
Publicado: (2015)

Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos
por: Mayxay, Mayfong, et al.
Publicado: (2012)

Diagnostic Performance of Plasmodium falciparum Histidine-Rich Protein-2 Antigen-Specific Rapid Diagnostic Test in Children at the Peripheral Health Care Level in Nanoro (Burkina Faso)
por: Bonko, Massa dit Achille, et al.
Publicado: (2022)

Molecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine–pyrimethamine in Tanzania
por: Kavishe, Reginald A., et al.
Publicado: (2016)

Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis
por: Saito, Makoto, et al.
Publicado: (2020)

High cure rates and tolerability of artesunate–amodiaquine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Kibaha and Kigoma, Tanzania
por: Mandara, Celine I., et al.
Publicado: (2019)

Simple Field Assays to Check Quality of Current Artemisinin-Based Antimalarial Combination Formulations
por: Ioset, Jean-Robert, et al.
Publicado: (2009)

High efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Muheza and Kigoma Districts, Tanzania
por: Mandara, Celine I., et al.
Publicado: (2018)

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa
por: Ndwiga, Leonard, et al.
Publicado: (2021)

Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children
por: Muwanguzi, Julian, et al.
Publicado: (2016)

Efficacy of Artemisinin-Based Combination Treatments of Uncomplicated Falciparum Malaria in Under-Five-Year-Old Nigerian Children
por: Oguche, Stephen, et al.
Publicado: (2014)

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis
por: Maiga, Fatoumata O., et al.
Publicado: (2021)

Algorithms for sequential interpretation of a malaria rapid diagnostic test detecting two different targets of Plasmodium species to improve diagnostic accuracy in a rural setting (Nanoro, Burkina Faso)
por: Kiemde, Francois, et al.
Publicado: (2019)

Seroepidemiology of canine leishmaniosis in Évora (southern Portugal): 20-year trends
por: Schallig, Henk DFH, et al.
Publicado: (2013)

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial
por: van der Pluijm, Rob W, et al.
Publicado: (2020)

Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria
por: Jamsen, Kris M, et al.
Publicado: (2012)

Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria
por: Muhindo, Mary K, et al.
Publicado: (2014)

Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
por: Bukirwa, Hasifa, et al.
Publicado: (2006)

Efficacy of Artemisinin Base Combination Therapy and Genetic Diversity of Plasmodium falciparum from Uncomplicated Malaria Falciparum Patient in District of Pesawaran, Province of Lampung, Indonesia
por: SUWANDI, Jhons Fatriyadi, et al.
Publicado: (2019)

A systematic review of published antimalarial clinical trials: parasite clearance of artemisinin-containing regimens in the treatment of uncomplicated malaria
por: Das, Debashish, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_bhq3abpmnf7m1k5lkkodi10do3