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dOCRL maintains immune cell quiescence by regulating endosomal traffic

Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL. OCRL plays diverse roles in endocytic and endolysosomal trafficking, cytokinesis, and ciliogenesis, but it is unclear which...

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Detalles Bibliográficos
Autores principales:	Del Signore, Steven J., Biber, Sarah A., Lehmann, Katherine S., Heimler, Stephanie R., Rosenfeld, Benjamin H., Eskin, Tania L., Sweeney, Sean T., Rodal, Avital A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656325/ https://www.ncbi.nlm.nih.gov/pubmed/29028801 http://dx.doi.org/10.1371/journal.pgen.1007052

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