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A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque

Despite the fact that technological advancements have been made in diagnosis and treatment, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Early detection of atherosclerosis (AS), especially vulnerable plaques, plays a crucial role in the prevention of...

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Autores principales: Anwaier, Gulinigaer, Chen, Cong, Cao, Yini, Qi, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656339/
https://www.ncbi.nlm.nih.gov/pubmed/29089763
http://dx.doi.org/10.2147/IJN.S142385
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author Anwaier, Gulinigaer
Chen, Cong
Cao, Yini
Qi, Rong
author_facet Anwaier, Gulinigaer
Chen, Cong
Cao, Yini
Qi, Rong
author_sort Anwaier, Gulinigaer
collection PubMed
description Despite the fact that technological advancements have been made in diagnosis and treatment, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Early detection of atherosclerosis (AS), especially vulnerable plaques, plays a crucial role in the prevention of acute coronary syndrome (ACS). Targeting the critical cytokines and molecules that are upregulated during the biological process of AS by in vivo molecular imaging has been widely used in plaque imaging. With their three-dimensional architecture, composition, and abundant terminal functional groups, dendrimers provide a platform for multitargeting and multimodal imaging. Thus, modified dendrimers with the key molecules upregulated in AS plaques will be an innovative attempt to achieve targeted imaging of AS plaques specifically and efficiently. This review was aimed to address some recent works on imaging of AS plaques using various types of image technology and further discuss the applications of dendrimers, an innovative yet seldom used method in imaging of AS plaques due to some limitations and challenges, and we highlight the bright future of the modified dendrimers in characterizing AS plaques.
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spelling pubmed-56563392017-10-31 A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque Anwaier, Gulinigaer Chen, Cong Cao, Yini Qi, Rong Int J Nanomedicine Review Despite the fact that technological advancements have been made in diagnosis and treatment, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Early detection of atherosclerosis (AS), especially vulnerable plaques, plays a crucial role in the prevention of acute coronary syndrome (ACS). Targeting the critical cytokines and molecules that are upregulated during the biological process of AS by in vivo molecular imaging has been widely used in plaque imaging. With their three-dimensional architecture, composition, and abundant terminal functional groups, dendrimers provide a platform for multitargeting and multimodal imaging. Thus, modified dendrimers with the key molecules upregulated in AS plaques will be an innovative attempt to achieve targeted imaging of AS plaques specifically and efficiently. This review was aimed to address some recent works on imaging of AS plaques using various types of image technology and further discuss the applications of dendrimers, an innovative yet seldom used method in imaging of AS plaques due to some limitations and challenges, and we highlight the bright future of the modified dendrimers in characterizing AS plaques. Dove Medical Press 2017-10-19 /pmc/articles/PMC5656339/ /pubmed/29089763 http://dx.doi.org/10.2147/IJN.S142385 Text en © 2017 Anwaier et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Anwaier, Gulinigaer
Chen, Cong
Cao, Yini
Qi, Rong
A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title_full A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title_fullStr A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title_full_unstemmed A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title_short A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
title_sort review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656339/
https://www.ncbi.nlm.nih.gov/pubmed/29089763
http://dx.doi.org/10.2147/IJN.S142385
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