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Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance

AIM: To investigate the expression of annexin A5 in serum and tumor tissue of patients with colon cancer and to analyze its clinical significance. METHODS: Ninety-three patients with colon cancer treated at our hospital between February 2013 and March 2016 were included in an observation group, and...

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Autores principales: Sun, Chong-Bing, Zhao, Ai-Yan, Ji, Shuai, Han, Xiao-Qing, Sun, Zuo-Cheng, Wang, Meng-Chun, Zheng, Fu-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656464/
https://www.ncbi.nlm.nih.gov/pubmed/29093625
http://dx.doi.org/10.3748/wjg.v23.i39.7168
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author Sun, Chong-Bing
Zhao, Ai-Yan
Ji, Shuai
Han, Xiao-Qing
Sun, Zuo-Cheng
Wang, Meng-Chun
Zheng, Fu-Chang
author_facet Sun, Chong-Bing
Zhao, Ai-Yan
Ji, Shuai
Han, Xiao-Qing
Sun, Zuo-Cheng
Wang, Meng-Chun
Zheng, Fu-Chang
author_sort Sun, Chong-Bing
collection PubMed
description AIM: To investigate the expression of annexin A5 in serum and tumor tissue of patients with colon cancer and to analyze its clinical significance. METHODS: Ninety-three patients with colon cancer treated at our hospital between February 2013 and March 2016 were included in an observation group, and 40 healthy individuals were included in a control group. Enzyme-linked immunosorbent assay was performed to determine the serum level of annexin A5, while immunohistochemistry was performed to determine the expression of annexin A5 in cancer tissues. RESULTS: The serum level of annexin A5 was 0.184 ± 0.043 ng/mL in the observation group, which was significantly higher than that in the control group (P < 0.05). Annexin A5 expression was detected in 79.31% of the patients with lymph node metastasis, which was significantly higher than that in patients without lymph node metastasis (P < 0.05). Moreover, annexin A5 expression was detected in 86.96% of the patients with stage III to IV disease, which was significantly higher than that in patients with stage I to II disease (P < 0.05). The serum level of annexin A5 was 0.215 ± 0.044 ng/mL in patients whose tumors were positive for annexin A5 expression, which was significantly higher than that in patients whose tumors were negative for annexin A5 expression (P < 0.05). The serum level of annexin A5 was correlated with annexin A5 expression in colon cancer tissues (r = 0.312, P < 0.05). When a cutoff value of > 0.148 ng/mL for serum level of annexin A5 was used in the diagnosis of colon cancer, the sensitivity was 83.90%, and the specificity was 57.50%. CONCLUSION: For patients with colon cancer, annexin A5 expression in cancer tissues is related to lymph node metastasis and tumor grade. Serum level of annexin A5 is related to annexin A5 expression in cancer tissues and is of diagnostic relevance.
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spelling pubmed-56564642017-11-01 Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance Sun, Chong-Bing Zhao, Ai-Yan Ji, Shuai Han, Xiao-Qing Sun, Zuo-Cheng Wang, Meng-Chun Zheng, Fu-Chang World J Gastroenterol Observational Study AIM: To investigate the expression of annexin A5 in serum and tumor tissue of patients with colon cancer and to analyze its clinical significance. METHODS: Ninety-three patients with colon cancer treated at our hospital between February 2013 and March 2016 were included in an observation group, and 40 healthy individuals were included in a control group. Enzyme-linked immunosorbent assay was performed to determine the serum level of annexin A5, while immunohistochemistry was performed to determine the expression of annexin A5 in cancer tissues. RESULTS: The serum level of annexin A5 was 0.184 ± 0.043 ng/mL in the observation group, which was significantly higher than that in the control group (P < 0.05). Annexin A5 expression was detected in 79.31% of the patients with lymph node metastasis, which was significantly higher than that in patients without lymph node metastasis (P < 0.05). Moreover, annexin A5 expression was detected in 86.96% of the patients with stage III to IV disease, which was significantly higher than that in patients with stage I to II disease (P < 0.05). The serum level of annexin A5 was 0.215 ± 0.044 ng/mL in patients whose tumors were positive for annexin A5 expression, which was significantly higher than that in patients whose tumors were negative for annexin A5 expression (P < 0.05). The serum level of annexin A5 was correlated with annexin A5 expression in colon cancer tissues (r = 0.312, P < 0.05). When a cutoff value of > 0.148 ng/mL for serum level of annexin A5 was used in the diagnosis of colon cancer, the sensitivity was 83.90%, and the specificity was 57.50%. CONCLUSION: For patients with colon cancer, annexin A5 expression in cancer tissues is related to lymph node metastasis and tumor grade. Serum level of annexin A5 is related to annexin A5 expression in cancer tissues and is of diagnostic relevance. Baishideng Publishing Group Inc 2017-10-21 2017-10-21 /pmc/articles/PMC5656464/ /pubmed/29093625 http://dx.doi.org/10.3748/wjg.v23.i39.7168 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Sun, Chong-Bing
Zhao, Ai-Yan
Ji, Shuai
Han, Xiao-Qing
Sun, Zuo-Cheng
Wang, Meng-Chun
Zheng, Fu-Chang
Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title_full Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title_fullStr Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title_full_unstemmed Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title_short Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance
title_sort expression of annexin a5 in serum and tumor tissue of patients with colon cancer and its clinical significance
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656464/
https://www.ncbi.nlm.nih.gov/pubmed/29093625
http://dx.doi.org/10.3748/wjg.v23.i39.7168
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