CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction

Despite its established inter-individual variability, sildenafil has been the subject of only a few pharmacogenetic investigations, with limited data regarding the genetic modulators of its pharmacokinetics. We conducted a pharmacogenetic substudy of patients randomized to sildenafil (n = 85) in the...

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Detalles Bibliográficos
Autores principales: de Denus, Simon, Rouleau, Jean L., Mann, Douglas L., Huggins, Gordon S., Pereira, Naveen L., Shah, Svati H., Cappola, Thomas P., Fouodjio, René, Mongrain, Ian, Dubé, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656562/
https://www.ncbi.nlm.nih.gov/pubmed/28440343
http://dx.doi.org/10.1038/tpj.2017.8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656562/
https://www.ncbi.nlm.nih.gov/pubmed/28440343
http://dx.doi.org/10.1038/tpj.2017.8

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