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Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model

Type 2 diabetes is characterized by insulin tolerance in target cells followed by a reduction of pancreatic β-cell mass. Islet amyloid polypeptide oligomeric assemblies were shown to contribute to β-cell apoptosis by forming discrete pores that destabilize the cellular membrane. We previously charac...

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Detalles Bibliográficos
Autores principales:	Bram, Yaron, Peled, Sivan, Brahmachari, Sayanti, Harlev, Michael, Gazit, Ehud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656574/ https://www.ncbi.nlm.nih.gov/pubmed/29070797 http://dx.doi.org/10.1038/s41598-017-14311-1

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