Language lateralization during the Chinese semantic task relates to the contralateral cerebra-cerebellar interactions at rest

Aiming to investigate whether handedness-related language lateralization is related to the intrinsic resting-state functional connectivity (RSFC) pattern within the language network, the present study integrated the information of functional activations during a semantic task of Chinese characters and FC in resting-state based on functional magnetic resonance imaging (fMRI) data of healthy left handers (LH) and right handers (RH). RSFC was calculated on a voxel-based level between the seed regions chosen from functional activations during the task and the rest of the brain. The results demonstrated that LH had significantly stronger RSFC than RH between the cerebellum and supratentorial areas of the frontal, parietal and temporal lobe, and between the occipital lobe and frontal/parietal lobe. Correlation analysis showed that RSFC values between right MFG and left cerebellum_crus2, between SMA and right cerebellum_crus2, and between the right cerebellum_crus1 and left MFG were negatively correlated with cerebral laterality index in LH and RH groups. Our results highlight key nodes of Chinese language brain network processing in the cerebellum, and suggest that atypical language dominance relates to stronger crossed reciprocal RSFC in the frontal-cerebellar system. The findings provide new insights into the intrinsic FC substrates underlying the atypical language lateralization of LH.