Cargando…

Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform

Wiring a series of simple logic gates to process complex data is significantly important and a large challenge for untraditional molecular computing systems. The programmable property of DNA endows its powerful application in molecular computing. In our investigation, it was found that DNA exhibits...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Jinting, Liu, Yaqing, Lin, Xiaodong, Deng, Jiankang, Yin, Jinjin, Wang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656625/
https://www.ncbi.nlm.nih.gov/pubmed/29070871
http://dx.doi.org/10.1038/s41598-017-14416-7
_version_ 1783273725968252928
author Gao, Jinting
Liu, Yaqing
Lin, Xiaodong
Deng, Jiankang
Yin, Jinjin
Wang, Shuo
author_facet Gao, Jinting
Liu, Yaqing
Lin, Xiaodong
Deng, Jiankang
Yin, Jinjin
Wang, Shuo
author_sort Gao, Jinting
collection PubMed
description Wiring a series of simple logic gates to process complex data is significantly important and a large challenge for untraditional molecular computing systems. The programmable property of DNA endows its powerful application in molecular computing. In our investigation, it was found that DNA exhibits excellent peroxidase-like activity in a colorimetric system of TMB/H(2)O(2)/Hemin (TMB, 3,3′, 5,5′-Tetramethylbenzidine) in the presence of K(+) and Cu(2+), which is significantly inhibited by the addition of an antioxidant. According to the modulated catalytic activity of this DNA-based catalyst, three cascade logic gates including AND-OR-INH (INHIBIT), AND-INH and OR-INH were successfully constructed. Interestingly, by only modulating the concentration of Cu(2+), a majority logic gate with a single-vote veto function was realized following the same threshold value as that of the cascade logic gates. The strategy is quite straightforward and versatile and provides an instructive method for constructing multiple logic gates on a simple platform to implement complex molecular computing.
format Online
Article
Text
id pubmed-5656625
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-56566252017-10-31 Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform Gao, Jinting Liu, Yaqing Lin, Xiaodong Deng, Jiankang Yin, Jinjin Wang, Shuo Sci Rep Article Wiring a series of simple logic gates to process complex data is significantly important and a large challenge for untraditional molecular computing systems. The programmable property of DNA endows its powerful application in molecular computing. In our investigation, it was found that DNA exhibits excellent peroxidase-like activity in a colorimetric system of TMB/H(2)O(2)/Hemin (TMB, 3,3′, 5,5′-Tetramethylbenzidine) in the presence of K(+) and Cu(2+), which is significantly inhibited by the addition of an antioxidant. According to the modulated catalytic activity of this DNA-based catalyst, three cascade logic gates including AND-OR-INH (INHIBIT), AND-INH and OR-INH were successfully constructed. Interestingly, by only modulating the concentration of Cu(2+), a majority logic gate with a single-vote veto function was realized following the same threshold value as that of the cascade logic gates. The strategy is quite straightforward and versatile and provides an instructive method for constructing multiple logic gates on a simple platform to implement complex molecular computing. Nature Publishing Group UK 2017-10-25 /pmc/articles/PMC5656625/ /pubmed/29070871 http://dx.doi.org/10.1038/s41598-017-14416-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gao, Jinting
Liu, Yaqing
Lin, Xiaodong
Deng, Jiankang
Yin, Jinjin
Wang, Shuo
Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title_full Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title_fullStr Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title_full_unstemmed Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title_short Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
title_sort implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656625/
https://www.ncbi.nlm.nih.gov/pubmed/29070871
http://dx.doi.org/10.1038/s41598-017-14416-7
work_keys_str_mv AT gaojinting implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform
AT liuyaqing implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform
AT linxiaodong implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform
AT dengjiankang implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform
AT yinjinjin implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform
AT wangshuo implementationofcascadelogicgatesandmajoritylogicgateonasimpleanduniversalmolecularplatform