Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding

PROPPINs (β-propellers that bind polyphosphoinositides) are PtdIns3P and PtdIns(3,5)P(2) binding autophagy related proteins. They contain two phosphatidylinositolphosphate (PIP) binding sites and a conserved FRRG motif is essential for PIP binding. Here we present the 2.0 Å resolution crystal struct...

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Detalles Bibliográficos
Autores principales: Scacioc, Andreea, Schmidt, Carla, Hofmann, Tommy, Urlaub, Henning, Kühnel, Karin, Pérez-Lara, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656675/
https://www.ncbi.nlm.nih.gov/pubmed/29070817
http://dx.doi.org/10.1038/s41598-017-14337-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656675/
https://www.ncbi.nlm.nih.gov/pubmed/29070817
http://dx.doi.org/10.1038/s41598-017-14337-5

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