Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, c...

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Autores principales: Mathew, Bini, Hobrath, Judith V., Lu, Wenyan, Li, Yonghe, Reynolds, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656725/
https://www.ncbi.nlm.nih.gov/pubmed/29104411
http://dx.doi.org/10.1007/s00044-017-2001-z
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author Mathew, Bini
Hobrath, Judith V.
Lu, Wenyan
Li, Yonghe
Reynolds, Robert C.
author_facet Mathew, Bini
Hobrath, Judith V.
Lu, Wenyan
Li, Yonghe
Reynolds, Robert C.
author_sort Mathew, Bini
collection PubMed
description As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.
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spelling pubmed-56567252017-11-01 Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens Mathew, Bini Hobrath, Judith V. Lu, Wenyan Li, Yonghe Reynolds, Robert C. Med Chem Res Original Research As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling. Springer US 2017-08-05 2017 /pmc/articles/PMC5656725/ /pubmed/29104411 http://dx.doi.org/10.1007/s00044-017-2001-z Text en © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Mathew, Bini
Hobrath, Judith V.
Lu, Wenyan
Li, Yonghe
Reynolds, Robert C.
Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title_full Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title_fullStr Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title_full_unstemmed Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title_short Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
title_sort synthesis and preliminary assessment of the anticancer and wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656725/
https://www.ncbi.nlm.nih.gov/pubmed/29104411
http://dx.doi.org/10.1007/s00044-017-2001-z
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