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Axl is not an indispensable factor for Zika virus infection in mice

Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain–Barré syndrome and severe fetal abnormalities. However, the mechanism underlying the interaction of ZIKV with host cells is not yet clear. Axl, a receptor tyrosine kinase, is postulated as a receptor...

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Autores principales: Wang, Zhao-Yang, Wang, Zai, Zhen, Zi-Da, Feng, Kai-Hao, Guo, Jing, Gao, Na, Fan, Dong-Ying, Han, Dai-Shu, Wang, Pei-Gang, An, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656784/
https://www.ncbi.nlm.nih.gov/pubmed/28786784
http://dx.doi.org/10.1099/jgv.0.000886
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author Wang, Zhao-Yang
Wang, Zai
Zhen, Zi-Da
Feng, Kai-Hao
Guo, Jing
Gao, Na
Fan, Dong-Ying
Han, Dai-Shu
Wang, Pei-Gang
An, Jing
author_facet Wang, Zhao-Yang
Wang, Zai
Zhen, Zi-Da
Feng, Kai-Hao
Guo, Jing
Gao, Na
Fan, Dong-Ying
Han, Dai-Shu
Wang, Pei-Gang
An, Jing
author_sort Wang, Zhao-Yang
collection PubMed
description Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain–Barré syndrome and severe fetal abnormalities. However, the mechanism underlying the interaction of ZIKV with host cells is not yet clear. Axl, a receptor tyrosine kinase, is postulated as a receptor for ZIKV entry; however, its in vivo role during ZIKV infection and its impact on the outcome of the disease have not been fully characterized and evaluated. Moreover, there are contradictory results on its involvement in ZIKV infection. Here we utilized Axl-deficient mice (Axl(−/−)) and their littermates (Axl(+/−)) to study the in vivo role of Axl in ZIKV infection. Our results showed that both Axl(+/−) and Axl(−/−) suckling mice supported the replication of ZIKV and presented clinical manifestations. No significant difference has been found between Axl-deficient mice and their littermates in terms of the survival rate, clinical manifestations, viral load, ZIKV distribution and histopathological changes in major organs. These results therefore indicate that Axl is not an indispensable factor for ZIKV infection in mice.
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spelling pubmed-56567842017-11-14 Axl is not an indispensable factor for Zika virus infection in mice Wang, Zhao-Yang Wang, Zai Zhen, Zi-Da Feng, Kai-Hao Guo, Jing Gao, Na Fan, Dong-Ying Han, Dai-Shu Wang, Pei-Gang An, Jing J Gen Virol Research Article Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain–Barré syndrome and severe fetal abnormalities. However, the mechanism underlying the interaction of ZIKV with host cells is not yet clear. Axl, a receptor tyrosine kinase, is postulated as a receptor for ZIKV entry; however, its in vivo role during ZIKV infection and its impact on the outcome of the disease have not been fully characterized and evaluated. Moreover, there are contradictory results on its involvement in ZIKV infection. Here we utilized Axl-deficient mice (Axl(−/−)) and their littermates (Axl(+/−)) to study the in vivo role of Axl in ZIKV infection. Our results showed that both Axl(+/−) and Axl(−/−) suckling mice supported the replication of ZIKV and presented clinical manifestations. No significant difference has been found between Axl-deficient mice and their littermates in terms of the survival rate, clinical manifestations, viral load, ZIKV distribution and histopathological changes in major organs. These results therefore indicate that Axl is not an indispensable factor for ZIKV infection in mice. Microbiology Society 2017-08 2017-08-08 /pmc/articles/PMC5656784/ /pubmed/28786784 http://dx.doi.org/10.1099/jgv.0.000886 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wang, Zhao-Yang
Wang, Zai
Zhen, Zi-Da
Feng, Kai-Hao
Guo, Jing
Gao, Na
Fan, Dong-Ying
Han, Dai-Shu
Wang, Pei-Gang
An, Jing
Axl is not an indispensable factor for Zika virus infection in mice
title Axl is not an indispensable factor for Zika virus infection in mice
title_full Axl is not an indispensable factor for Zika virus infection in mice
title_fullStr Axl is not an indispensable factor for Zika virus infection in mice
title_full_unstemmed Axl is not an indispensable factor for Zika virus infection in mice
title_short Axl is not an indispensable factor for Zika virus infection in mice
title_sort axl is not an indispensable factor for zika virus infection in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656784/
https://www.ncbi.nlm.nih.gov/pubmed/28786784
http://dx.doi.org/10.1099/jgv.0.000886
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