Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

Quinone‐based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4‐benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutan...

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Detalles Bibliográficos
Autores principales: Meredith, Emma Louise, Kumar, Ambika, Konno, Aya, Szular, Joanna, Alsford, Sam, Seifert, Karin, Horn, David, Wilkinson, Shane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656836/
https://www.ncbi.nlm.nih.gov/pubmed/28792090
http://dx.doi.org/10.1111/mmi.13767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656836/
https://www.ncbi.nlm.nih.gov/pubmed/28792090
http://dx.doi.org/10.1111/mmi.13767

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