Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins

The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3′‐deoxyuridine that they share. This moiety is generated by an unusual,...

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Detalles Bibliográficos
Autores principales: Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Bent, Andrew F., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656905/
https://www.ncbi.nlm.nih.gov/pubmed/28786545
http://dx.doi.org/10.1002/anie.201705639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656905/
https://www.ncbi.nlm.nih.gov/pubmed/28786545
http://dx.doi.org/10.1002/anie.201705639

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