Reduced number of CD169(+) macrophages in pre‐metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients

BACKGROUND: Tumor‐derived antigens are captured by CD169(+) (SIGLEC1(+)) sinus macrophages in regional lymph nodes (LNs), and are presented to effector cells inducing an anti‐tumor immune response. Reduced CD169 expression in pre‐metastatic regional LNs is associated with subsequent metastatic disea...

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Detalles Bibliográficos
Autores principales: Strömvall, Kerstin, Sundkvist, Kristoffer, Ljungberg, Börje, Halin Bergström, Sofia, Bergh, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656907/
https://www.ncbi.nlm.nih.gov/pubmed/28880401
http://dx.doi.org/10.1002/pros.23407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656907/
https://www.ncbi.nlm.nih.gov/pubmed/28880401
http://dx.doi.org/10.1002/pros.23407

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