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Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma a...

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Autores principales: Mirabelli, Carmen, Scheers, Els, Neyts, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657016/
https://www.ncbi.nlm.nih.gov/pubmed/29123648
http://dx.doi.org/10.12688/f1000research.11978.1
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author Mirabelli, Carmen
Scheers, Els
Neyts, Johan
author_facet Mirabelli, Carmen
Scheers, Els
Neyts, Johan
author_sort Mirabelli, Carmen
collection PubMed
description Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.
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spelling pubmed-56570162017-11-08 Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis Mirabelli, Carmen Scheers, Els Neyts, Johan F1000Res Review Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD. F1000Research 2017-10-19 /pmc/articles/PMC5657016/ /pubmed/29123648 http://dx.doi.org/10.12688/f1000research.11978.1 Text en Copyright: © 2017 Mirabelli C et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mirabelli, Carmen
Scheers, Els
Neyts, Johan
Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title_full Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title_fullStr Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title_full_unstemmed Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title_short Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis
title_sort novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/copd pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657016/
https://www.ncbi.nlm.nih.gov/pubmed/29123648
http://dx.doi.org/10.12688/f1000research.11978.1
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