RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan

Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Result...

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Autores principales: Park, Sangsoon, Jung, Yoonji, An, Seon Woo A., Son, Heehwa G., Hwang, Wooseon, Lee, Dongyeop, Artan, Murat, Park, Hae-Eun H., Jeong, Dae-Eun, Lee, Yujin, Lee, Seung-Jae V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657022/
https://www.ncbi.nlm.nih.gov/pubmed/29123644
http://dx.doi.org/10.12688/f1000research.12337.4
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author Park, Sangsoon
Jung, Yoonji
An, Seon Woo A.
Son, Heehwa G.
Hwang, Wooseon
Lee, Dongyeop
Artan, Murat
Park, Hae-Eun H.
Jeong, Dae-Eun
Lee, Yujin
Lee, Seung-Jae V.
author_facet Park, Sangsoon
Jung, Yoonji
An, Seon Woo A.
Son, Heehwa G.
Hwang, Wooseon
Lee, Dongyeop
Artan, Murat
Park, Hae-Eun H.
Jeong, Dae-Eun
Lee, Yujin
Lee, Seung-Jae V.
author_sort Park, Sangsoon
collection PubMed
description Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that feeding worms with bacteria expressing double-stranded RNA against each of 24 out of total 29 C. elegans α-arrestins had little effect on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.
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spelling pubmed-56570222017-11-08 RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan Park, Sangsoon Jung, Yoonji An, Seon Woo A. Son, Heehwa G. Hwang, Wooseon Lee, Dongyeop Artan, Murat Park, Hae-Eun H. Jeong, Dae-Eun Lee, Yujin Lee, Seung-Jae V. F1000Res Research Article Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that feeding worms with bacteria expressing double-stranded RNA against each of 24 out of total 29 C. elegans α-arrestins had little effect on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity. F1000 Research Limited 2017-12-08 /pmc/articles/PMC5657022/ /pubmed/29123644 http://dx.doi.org/10.12688/f1000research.12337.4 Text en Copyright: © 2017 Park S et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Park, Sangsoon
Jung, Yoonji
An, Seon Woo A.
Son, Heehwa G.
Hwang, Wooseon
Lee, Dongyeop
Artan, Murat
Park, Hae-Eun H.
Jeong, Dae-Eun
Lee, Yujin
Lee, Seung-Jae V.
RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title_full RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title_fullStr RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title_full_unstemmed RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title_short RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
title_sort rnai targeting caenorhabditis elegans α-arrestins has little effect on lifespan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657022/
https://www.ncbi.nlm.nih.gov/pubmed/29123644
http://dx.doi.org/10.12688/f1000research.12337.4
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