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Neurons generated from carcinoma stem cells support cancer progression

Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neuron...

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Autores principales: Lu, Ran, Fan, Chuanwen, Shangguan, Wenqi, Liu, Yuan, Li, Yu, Shang, Yanna, Yin, Dongqin, Zhang, Shengliang, Huang, Qiaorong, Li, Xue, Meng, Wentong, Xu, Hong, Zhou, Zongguang, Hu, Jiankun, Li, Weimin, Liu, Lunxu, Mo, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657421/
https://www.ncbi.nlm.nih.gov/pubmed/29263908
http://dx.doi.org/10.1038/sigtrans.2016.36
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author Lu, Ran
Fan, Chuanwen
Shangguan, Wenqi
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Li, Weimin
Liu, Lunxu
Mo, Xianming
author_facet Lu, Ran
Fan, Chuanwen
Shangguan, Wenqi
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Li, Weimin
Liu, Lunxu
Mo, Xianming
author_sort Lu, Ran
collection PubMed
description Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated. However, how the nervous system is built in cancer is largely unknown. Here we show that a fraction of cancer stem cells (CSCs) derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth. Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues. Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model. Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression.
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spelling pubmed-56574212017-12-20 Neurons generated from carcinoma stem cells support cancer progression Lu, Ran Fan, Chuanwen Shangguan, Wenqi Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Li, Weimin Liu, Lunxu Mo, Xianming Signal Transduct Target Ther Article Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated. However, how the nervous system is built in cancer is largely unknown. Here we show that a fraction of cancer stem cells (CSCs) derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth. Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues. Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model. Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. Nature Publishing Group 2017-01-06 /pmc/articles/PMC5657421/ /pubmed/29263908 http://dx.doi.org/10.1038/sigtrans.2016.36 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Ran
Fan, Chuanwen
Shangguan, Wenqi
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Li, Weimin
Liu, Lunxu
Mo, Xianming
Neurons generated from carcinoma stem cells support cancer progression
title Neurons generated from carcinoma stem cells support cancer progression
title_full Neurons generated from carcinoma stem cells support cancer progression
title_fullStr Neurons generated from carcinoma stem cells support cancer progression
title_full_unstemmed Neurons generated from carcinoma stem cells support cancer progression
title_short Neurons generated from carcinoma stem cells support cancer progression
title_sort neurons generated from carcinoma stem cells support cancer progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657421/
https://www.ncbi.nlm.nih.gov/pubmed/29263908
http://dx.doi.org/10.1038/sigtrans.2016.36
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