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Neurons generated from carcinoma stem cells support cancer progression
Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neuron...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657421/ https://www.ncbi.nlm.nih.gov/pubmed/29263908 http://dx.doi.org/10.1038/sigtrans.2016.36 |
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author | Lu, Ran Fan, Chuanwen Shangguan, Wenqi Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Li, Weimin Liu, Lunxu Mo, Xianming |
author_facet | Lu, Ran Fan, Chuanwen Shangguan, Wenqi Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Li, Weimin Liu, Lunxu Mo, Xianming |
author_sort | Lu, Ran |
collection | PubMed |
description | Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated. However, how the nervous system is built in cancer is largely unknown. Here we show that a fraction of cancer stem cells (CSCs) derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth. Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues. Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model. Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. |
format | Online Article Text |
id | pubmed-5657421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56574212017-12-20 Neurons generated from carcinoma stem cells support cancer progression Lu, Ran Fan, Chuanwen Shangguan, Wenqi Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Li, Weimin Liu, Lunxu Mo, Xianming Signal Transduct Target Ther Article Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated. However, how the nervous system is built in cancer is largely unknown. Here we show that a fraction of cancer stem cells (CSCs) derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth. Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues. Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model. Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. Nature Publishing Group 2017-01-06 /pmc/articles/PMC5657421/ /pubmed/29263908 http://dx.doi.org/10.1038/sigtrans.2016.36 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lu, Ran Fan, Chuanwen Shangguan, Wenqi Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Li, Weimin Liu, Lunxu Mo, Xianming Neurons generated from carcinoma stem cells support cancer progression |
title | Neurons generated from carcinoma stem cells support cancer progression |
title_full | Neurons generated from carcinoma stem cells support cancer progression |
title_fullStr | Neurons generated from carcinoma stem cells support cancer progression |
title_full_unstemmed | Neurons generated from carcinoma stem cells support cancer progression |
title_short | Neurons generated from carcinoma stem cells support cancer progression |
title_sort | neurons generated from carcinoma stem cells support cancer progression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657421/ https://www.ncbi.nlm.nih.gov/pubmed/29263908 http://dx.doi.org/10.1038/sigtrans.2016.36 |
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