Ensemble cryo-EM elucidates the mechanism of translation fidelity

Faithful gene translation depends on accurate decoding, whose structural mechanism remains a matter of debate. Ribosomes decode mRNA codons by selecting cognate aminoacyl-tRNAs delivered by EF-Tu. We present high-resolution structural ensembles of ribosomes with cognate or near-cognate aminoacyl-tRN...

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Detalles Bibliográficos
Autores principales: Loveland, Anna B., Demo, Gabriel, Grigorieff, Nikolaus, Korostelev, Andrei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657493/
https://www.ncbi.nlm.nih.gov/pubmed/28538735
http://dx.doi.org/10.1038/nature22397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657493/
https://www.ncbi.nlm.nih.gov/pubmed/28538735
http://dx.doi.org/10.1038/nature22397

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