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Toxicity and repair of DNA adducts produced by the natural product yatakemycin

Yatakemycin (YTM) is an extraordinarily toxic DNA alkylating agent with potent antimicrobial and antitumor properties and the most recent addition to the CC-1065 and duocarmycin family of natural products. While bulky DNA lesions the size of those produced by YTM are normally removed from the genome...

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Detalles Bibliográficos
Autores principales:	Mullins, Elwood A., Shi, Rongxin, Eichman, Brandt F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657529/ https://www.ncbi.nlm.nih.gov/pubmed/28759018 http://dx.doi.org/10.1038/nchembio.2439

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