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Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors

Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively base...

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Autores principales: Galgano, Michael, Toshkezi, Gentian, Qiu, Xuecheng, Russell, Thomas, Chin, Lawrence, Zhao, Li-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657730/
https://www.ncbi.nlm.nih.gov/pubmed/28933211
http://dx.doi.org/10.1177/0963689717714102
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author Galgano, Michael
Toshkezi, Gentian
Qiu, Xuecheng
Russell, Thomas
Chin, Lawrence
Zhao, Li-Ru
author_facet Galgano, Michael
Toshkezi, Gentian
Qiu, Xuecheng
Russell, Thomas
Chin, Lawrence
Zhao, Li-Ru
author_sort Galgano, Michael
collection PubMed
description Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance. In this review article, we have summarized the current status of treatment for TBI in both clinical practice and basic research. We have put forth a brief overview of the various subtypes of traumatic injuries, optimal medical management, and both the noninvasive and invasive monitoring modalities, in addition to the surgical interventions necessary in particular instances. We have overviewed the main achievements in searching for therapeutic strategies of TBI in basic science. We have also discussed the future direction for developing TBI treatment from an experimental perspective.
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spelling pubmed-56577302017-11-08 Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors Galgano, Michael Toshkezi, Gentian Qiu, Xuecheng Russell, Thomas Chin, Lawrence Zhao, Li-Ru Cell Transplant Traumatic Brain Injury Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance. In this review article, we have summarized the current status of treatment for TBI in both clinical practice and basic research. We have put forth a brief overview of the various subtypes of traumatic injuries, optimal medical management, and both the noninvasive and invasive monitoring modalities, in addition to the surgical interventions necessary in particular instances. We have overviewed the main achievements in searching for therapeutic strategies of TBI in basic science. We have also discussed the future direction for developing TBI treatment from an experimental perspective. SAGE Publications 2017-06-30 2017-07 /pmc/articles/PMC5657730/ /pubmed/28933211 http://dx.doi.org/10.1177/0963689717714102 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Traumatic Brain Injury
Galgano, Michael
Toshkezi, Gentian
Qiu, Xuecheng
Russell, Thomas
Chin, Lawrence
Zhao, Li-Ru
Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title_full Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title_fullStr Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title_full_unstemmed Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title_short Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors
title_sort traumatic brain injury: current treatment strategies and future endeavors
topic Traumatic Brain Injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657730/
https://www.ncbi.nlm.nih.gov/pubmed/28933211
http://dx.doi.org/10.1177/0963689717714102
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