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Thrombosis after liver transplantation for hepatocellular carcinoma
The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. We investigated a co...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658078/ https://www.ncbi.nlm.nih.gov/pubmed/29073275 http://dx.doi.org/10.1371/journal.pone.0186699 |
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author | Martinelli, Ida Ponziani, Francesca R. Maino, Alberto Bhoori, Sherrie Abbattista, Maria Maggi, Umberto De Feo, Tullia M. Bucciarelli, Paolo Artoni, Andrea Longhi, Elena Serafini, Marta Rossi, Giorgio Mazzaferro, Vincenzo |
author_facet | Martinelli, Ida Ponziani, Francesca R. Maino, Alberto Bhoori, Sherrie Abbattista, Maria Maggi, Umberto De Feo, Tullia M. Bucciarelli, Paolo Artoni, Andrea Longhi, Elena Serafini, Marta Rossi, Giorgio Mazzaferro, Vincenzo |
author_sort | Martinelli, Ida |
collection | PubMed |
description | The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. We investigated a cohort of patients who underwent LT for HCC with the aim to estimate the incidence rate (IR) of thrombosis, its influence on mortality and re-transplantation rates and, in the frame of a nested case-control study, the role of thrombophilia in donors and recipients for the development of thrombosis. Four-hundred and thirty patients underwent LT and were followed for a median of 7.2 years. Twenty-six recipients (6%) developed thrombosis (IR 1.06 [95%CI: 0.71–1.53] per 100 pts-yr). Mortality rate after LT was 3.95 (95%CI: 3.22–4.79) per 100 pts-yr and was not influenced by thrombosis. Re-transplantation was planned for 33 patients and was more common in patients with thrombosis than in those without (HR 2.50 [95%CI: 0.87–7.17]). The risk of thrombosis was 4 times higher in recipients with thrombophilia than in those without (OR 4.23 [95%CI: 0.99–18.04]) and 6 times higher when the analysis was restricted to venous thrombosis (OR 6.26 [95%CI: 1.19–32.85]). The presence of inherited thrombophilia in the donors did not increase the risk of thrombosis of the recipient. In conclusion, thrombosis is a complication of 6% of patients transplanted for HCC and increases the risk of re-transplantation but not of mortality. The risk of thrombosis, particularly venous, is increased in the presence of thrombophilia abnormalities in the recipients. |
format | Online Article Text |
id | pubmed-5658078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56580782017-11-09 Thrombosis after liver transplantation for hepatocellular carcinoma Martinelli, Ida Ponziani, Francesca R. Maino, Alberto Bhoori, Sherrie Abbattista, Maria Maggi, Umberto De Feo, Tullia M. Bucciarelli, Paolo Artoni, Andrea Longhi, Elena Serafini, Marta Rossi, Giorgio Mazzaferro, Vincenzo PLoS One Research Article The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. We investigated a cohort of patients who underwent LT for HCC with the aim to estimate the incidence rate (IR) of thrombosis, its influence on mortality and re-transplantation rates and, in the frame of a nested case-control study, the role of thrombophilia in donors and recipients for the development of thrombosis. Four-hundred and thirty patients underwent LT and were followed for a median of 7.2 years. Twenty-six recipients (6%) developed thrombosis (IR 1.06 [95%CI: 0.71–1.53] per 100 pts-yr). Mortality rate after LT was 3.95 (95%CI: 3.22–4.79) per 100 pts-yr and was not influenced by thrombosis. Re-transplantation was planned for 33 patients and was more common in patients with thrombosis than in those without (HR 2.50 [95%CI: 0.87–7.17]). The risk of thrombosis was 4 times higher in recipients with thrombophilia than in those without (OR 4.23 [95%CI: 0.99–18.04]) and 6 times higher when the analysis was restricted to venous thrombosis (OR 6.26 [95%CI: 1.19–32.85]). The presence of inherited thrombophilia in the donors did not increase the risk of thrombosis of the recipient. In conclusion, thrombosis is a complication of 6% of patients transplanted for HCC and increases the risk of re-transplantation but not of mortality. The risk of thrombosis, particularly venous, is increased in the presence of thrombophilia abnormalities in the recipients. Public Library of Science 2017-10-26 /pmc/articles/PMC5658078/ /pubmed/29073275 http://dx.doi.org/10.1371/journal.pone.0186699 Text en © 2017 Martinelli et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Martinelli, Ida Ponziani, Francesca R. Maino, Alberto Bhoori, Sherrie Abbattista, Maria Maggi, Umberto De Feo, Tullia M. Bucciarelli, Paolo Artoni, Andrea Longhi, Elena Serafini, Marta Rossi, Giorgio Mazzaferro, Vincenzo Thrombosis after liver transplantation for hepatocellular carcinoma |
title | Thrombosis after liver transplantation for hepatocellular carcinoma |
title_full | Thrombosis after liver transplantation for hepatocellular carcinoma |
title_fullStr | Thrombosis after liver transplantation for hepatocellular carcinoma |
title_full_unstemmed | Thrombosis after liver transplantation for hepatocellular carcinoma |
title_short | Thrombosis after liver transplantation for hepatocellular carcinoma |
title_sort | thrombosis after liver transplantation for hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658078/ https://www.ncbi.nlm.nih.gov/pubmed/29073275 http://dx.doi.org/10.1371/journal.pone.0186699 |
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