Poly(ADP-ribose)polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H(2)O(2)

Poly(ADP-ribose)polymerases (PARPs) are a family of NAD(+) consuming enzymes that play a crucial role in many cellular processes, most clearly in maintaining genome integrity. Here, we present an extensive analysis of the alteration of mitochondrial morphology and the relationship to PARPs activity...

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Detalles Bibliográficos
Autores principales: Martín-Guerrero, Sandra M., Muñoz-Gámez, José A., Carrasco, María-Carmen, Salmerón, Javier, Martín-Estebané, María, Cuadros, Miguel A., Navascués, Julio, Martín-Oliva, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658148/
https://www.ncbi.nlm.nih.gov/pubmed/29073231
http://dx.doi.org/10.1371/journal.pone.0187130

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