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Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension

Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic injury models. In the 2-kidney 1-clip (2K1C) model of RVH, employing mice on the 129 genetic background, Smad3 deficiency (KO) protects the steno...

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Detalles Bibliográficos
Autores principales:	Kashyap, Sonu, Warner, Gina, Hu, Zeng, Gao, Feng, Osman, Mazen, Al Saiegh, Yousif, Lien, Karen R., Nath, Karl, Grande, Joseph P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658153/ https://www.ncbi.nlm.nih.gov/pubmed/29073282 http://dx.doi.org/10.1371/journal.pone.0187062

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