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Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1(-/-) mice have a reduction in the rate of cholesterol biosynthesis in the brain and significant impairments to memory and learning. To g...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658173/ https://www.ncbi.nlm.nih.gov/pubmed/29073233 http://dx.doi.org/10.1371/journal.pone.0187168 |