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Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing

Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can reactivate to start a productive infection, enabling spread of progeny virions to other hosts....

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Detalles Bibliográficos
Autores principales: Koyuncu, Orkide O., MacGibeny, Margaret A., Hogue, Ian B., Enquist, Lynn W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658187/
https://www.ncbi.nlm.nih.gov/pubmed/29073268
http://dx.doi.org/10.1371/journal.ppat.1006608