The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans

An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protei...

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Detalles Bibliográficos
Autores principales: Das, Ritika, Melo, Justine A., Thondamal, Manjunatha, Morton, Elizabeth A., Cornwell, Adam B., Crick, Beresford, Kim, Joung Heon, Swartz, Elliot W., Lamitina, Todd, Douglas, Peter M., Samuelson, Andrew V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658188/
https://www.ncbi.nlm.nih.gov/pubmed/29036198
http://dx.doi.org/10.1371/journal.pgen.1007038

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