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Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons
AIM: To determine whether hepatitis B virus (HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent country. METHODS: Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658321/ https://www.ncbi.nlm.nih.gov/pubmed/29097876 http://dx.doi.org/10.3748/wjg.v23.i38.7037 |
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author | Boyd, Anders Bottero, Julie Carrat, Fabrice Gozlan, Joël Rougier, Hayette Girard, Pierre-Marie Lacombe, Karine |
author_facet | Boyd, Anders Bottero, Julie Carrat, Fabrice Gozlan, Joël Rougier, Hayette Girard, Pierre-Marie Lacombe, Karine |
author_sort | Boyd, Anders |
collection | PubMed |
description | AIM: To determine whether hepatitis B virus (HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent country. METHODS: Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol (for all respondents) and intent-to-treat analysis (assuming all non-responders did not vaccinate). RESULTS: In total, 1215/4924 (24.7%) enrolled subjects with complete HBV serology were identified as non-immunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0% (95%CI: 9.0-13.2); intent-to-treat, 8.2% (95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries (P < 0.001), patients with limited healthcare coverage (P = 0.01) and men who have sex with men (P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was “will be vaccinated later” (33.4%), followed by “did not want to vaccinate” (29.8%), and “vaccination was not proposed by the physician” (21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%. CONCLUSION: HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level. |
format | Online Article Text |
id | pubmed-5658321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-56583212017-11-02 Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons Boyd, Anders Bottero, Julie Carrat, Fabrice Gozlan, Joël Rougier, Hayette Girard, Pierre-Marie Lacombe, Karine World J Gastroenterol Prospective Study AIM: To determine whether hepatitis B virus (HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent country. METHODS: Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol (for all respondents) and intent-to-treat analysis (assuming all non-responders did not vaccinate). RESULTS: In total, 1215/4924 (24.7%) enrolled subjects with complete HBV serology were identified as non-immunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0% (95%CI: 9.0-13.2); intent-to-treat, 8.2% (95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries (P < 0.001), patients with limited healthcare coverage (P = 0.01) and men who have sex with men (P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was “will be vaccinated later” (33.4%), followed by “did not want to vaccinate” (29.8%), and “vaccination was not proposed by the physician” (21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%. CONCLUSION: HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level. Baishideng Publishing Group Inc 2017-10-14 2017-10-14 /pmc/articles/PMC5658321/ /pubmed/29097876 http://dx.doi.org/10.3748/wjg.v23.i38.7037 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Prospective Study Boyd, Anders Bottero, Julie Carrat, Fabrice Gozlan, Joël Rougier, Hayette Girard, Pierre-Marie Lacombe, Karine Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title | Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title_full | Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title_fullStr | Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title_full_unstemmed | Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title_short | Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons |
title_sort | testing for hepatitis b virus alone does not increase vaccine coverage in non-immunized persons |
topic | Prospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658321/ https://www.ncbi.nlm.nih.gov/pubmed/29097876 http://dx.doi.org/10.3748/wjg.v23.i38.7037 |
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