Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

Upon oxidative stress and aging, Nrf2 (NFE2-related factor2) triggers antioxidant defense genes to defends against homeostatic failure. Using human(h) or rat(r) lens epithelial cells (LECs) and aging human lenses, we showed that a progressive increase in oxidative load during aging was linked to a d...

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Detalles Bibliográficos
Autores principales: Kubo, Eri, Chhunchha, Bhavana, Singh, Prerna, Sasaki, Hiroshi, Singh, Dhirendra P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658327/
https://www.ncbi.nlm.nih.gov/pubmed/29074861
http://dx.doi.org/10.1038/s41598-017-14520-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658327/
https://www.ncbi.nlm.nih.gov/pubmed/29074861
http://dx.doi.org/10.1038/s41598-017-14520-8

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