An HIV-positive Case of Obstructive Jaundice Caused by Immune Reconstitution Inflammatory Syndrome of Tuberculous Lymphadenitis Successfully Treated with Corticosteroids

A 60-year-old man was admitted to our hospital because of a persistent fever with enlargement of multiple lymph nodes in the mediastinum and around the pancreatic head. He was diagnosed with tuberculosis and human immunodeficiency virus infection. We started antiretroviral therapy three weeks after...

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Detalles Bibliográficos
Autores principales: Watanabe, Naoaki, Sato, Ryota, Nagai, Hideaki, Matsui, Hirotoshi, Yamane, Akira, Kawashima, Masahiro, Suzuki, Junko, Tashimo, Hiroyuki, Ohshima, Nobuharu, Masuda, Kimihiko, Tamura, Atsuhisa, Akagawa, Shinobu, Hebisawa, Akira, Ohta, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658536/
https://www.ncbi.nlm.nih.gov/pubmed/28883243
http://dx.doi.org/10.2169/internalmedicine.8713-16
Descripción
Sumario:A 60-year-old man was admitted to our hospital because of a persistent fever with enlargement of multiple lymph nodes in the mediastinum and around the pancreatic head. He was diagnosed with tuberculosis and human immunodeficiency virus infection. We started antiretroviral therapy three weeks after the initiation of anti-tuberculous therapy. Two weeks later, jaundice appeared with dilatation of the biliary tract due to further enlargement of the lymph nodes, which seemed to be immune reconstitution inflammatory syndrome (IRIS). The administration of corticosteroids resolved the obstructive jaundice without surgical treatment or endoscopic drainage. Obstructive jaundice caused by IRIS should first be treated with corticosteroids before invasive treatment.

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