Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT

In many cancer types, integrin-mediated signaling regulates proliferation, survival and invasion of tumorigenic cells. However, it is still unclear how integrins crosstalk with oncogenes to regulate tumorigenesis and metastasis. Here we show that oncogenic K-Ras(V12) upregulates α6-integrin expressi...

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Detalles Bibliográficos
Autores principales: Zhang, K, Myllymäki, S-M, Gao, P, Devarajan, R, Kytölä, V, Nykter, M, Wei, G-H, Manninen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658677/
https://www.ncbi.nlm.nih.gov/pubmed/28604746
http://dx.doi.org/10.1038/onc.2017.177

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