Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated Apc(Δ716) Trp...

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Detalles Bibliográficos
Autores principales: Nakayama, M, Sakai, E, Echizen, K, Yamada, Y, Oshima, H, Han, T-S, Ohki, R, Fujii, S, Ochiai, A, Robine, S, Voon, D C, Tanaka, T, Taketo, M M, Oshima, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658682/
https://www.ncbi.nlm.nih.gov/pubmed/28628120
http://dx.doi.org/10.1038/onc.2017.194

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